IL6 and neoplasm: Furthermore, based on the internal validation cohort (consisting of the training cohort and test cohort), univariate (Fig. 4a) and multivariate (Fig. 4b) Cox regression analyses suggested that the risk score, rather than the tumor stage, node stage, metastasis stage, or IL6 expression, was an independent risk factor for poor prognosis in the EAC patients (hazard ratio > 1; 95% CI not including 1).