In agreement with our findings, FR-β expression has previously been shown to be higher in anti-inflammatory macrophages and is also high in tumor-associated macrophages (TAM) that have a similar M2-like phenotype.31,35 We observed that FR-β expression was lower in IC-induced M2b-like macrophages, as was their expression of CD163 and CD16. The gene discussed is CD163; the disease is neoplasm.