CAV1 and hepatocellular carcinoma: We then investigate the biologicalrelevance of this mechanism by analyzing the expression of TIMP-1and caveolin-1 in cirrhosis and hepatocellular carcinoma (HCC), anddemonstrate these proteins are upregulated in chronic liver diseases,an effect that can be recapitulated on HSCs cultured on 3D matriceswith fibrosis-mimicking stiffness.