The dysregulation of ECM remodelingby hepatic stellate cells (HSCs), the main mediators of fibrosis,results in an elevated ECM stiffness that drives the development ofchronic liver disease such as cirrhosis and hepatocellular carcinoma.Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) is a key elementin the regulation of ECM remodeling, which modulates the degradationand turnover of ECM components. This evidence concerns the gene TIMP1 and hepatocellular carcinoma.