TCF4 and infection: Infection of activated whole PBMCs (n = 3 donors) over 7 days showed a modest yet significantly increased HIV transcripts in the TCF-4 binding site mutant infected cells, with 1.4 to 1.2 fold increase in intracellular HIV RNA on day 5 and day 7 post-infection (p = 0.018 and 0.043, respectively) (Fig 1G).