Of note, other 13 FOX members failed to show this trend (Supplementary Figure 1): 7 FOX proteins (FOXB1, FOXB2, FOXG1, FOXI1, FOXN1, FOXR1 and FOXR2) were undetectable in both HCC and liver tissues; 4 FOX members (FOXD3, FOXF1, FOXO1 and FOXP2) were under expressed in HCC patients; FOXA3 and FOXP3 were indistinguishably expressed between HCC and normal liver tissues. This evidence concerns the gene FOXO1 and hepatocellular carcinoma.