APC and colorectal carcinoma: Hence, to understand the significance of Kras mutations in CRC, we crossed LSL-Kras mice [B6.129-Krastm4Tyj (01XJ6) from NCI Mouse Models of Human Cancers Consortium, Frederick, MD, USA] [29] with AMC and generated Apc-/-;KrasG12D/+;Muc4-/-; Cdx2P-creERT2 (referred as AKMC) and its littermate controls Apc-/-; KrasG12D/+;Cdx2P-creERT2 (AKC) (Figure 7A).