Therefore, it seems that the post-translational modifications of Stim1 and Orai1 play a role in (cancer) cell migration and polarized plasma membrane organization, as demonstrated by several groups through RNA interference, gene-knock-out, or Stim1 overexpression systems (Chen et al. 2011; Mo and Yang 2018; Prevarskaya et al. 2014; Tsai et al. 2015; Yang et al. 2009). This evidence concerns the gene ORAI1 and cancer.