BARX2 and Alzheimer disease: Among other genes whose expression is modulated by E2F4DN with unclear purpose are Adi1, Barx2, Cfap46, and Cfap54. Adi1, which is upregulated in the cerebral cortex of 5xFAD/E2F4DN mice (Supplementary Fig. 11a), encodes acireductone dioxygenase 1, an enzyme that participates in the metabolism of methionine and is downregulated in subjects with AD [74].