AKT1 and metabolic syndrome: Cholesterol-lowering medications such as statins might mitigate the pro-tumorigenic effects of dyslipidemia.86 (2) Agents such as metformin and vitamin D3 that target the intracellular energy balance pathways (e.g., P13K/Akt/mTOR) might hold great promise to reverse the obesity-driven aggressiveness.100,101 (3) In theory, nonsteroidal anti-inflammatory drugs such as aspirin could be beneficial in treating local and systemic inflammation.