By using Western blotting, we found that IL-1β and Casp-1 maturation form protein expression with LPS along with Nigericin and SVA stimulation increased at different hours postinfection (hpi) or multiplicity of infections (MOIs) in supernatants and cell lysates of bone marrow-derived macrophages (BMDMs) cells compared with that with control conditions (Fig. 1H and I). The gene discussed is CASP1; the disease is infection.