DBP and infection: Moreover, the observation that UBM5 H5pm4251-infected cells consistently lack DBP-positive RCs from the early to the late phase of a productive infection supports the idea that HAdV-C5 DBP controls the initiation of viral RCs and, thus, a key step at the onset of the late phase and that this activity is intimately linked to its ability to regulate the formation and/or integrity of viral RCs, including viral DNA replication.