In contrast, at 24 h (Fig. 4A, panels e to g) and 48 h (Fig. 4B, panels a to c) after infection with WT H5pg4100, the intensity of diffuse nuclear staining was greatly reduced, and in all of the infected cells examined (n > 140), USP7 was clearly seen concentrated in DBP-positive RCs. The gene discussed is USP7; the disease is infection.