Inflammatory cytokines such as interleukin 6 (IL-6), IL-1β, and tumor necrosis factor (TNF) have been shown to be biomarkers of both acute and chronic CHIKVD (5), with levels of these cytokines also commonly being elevated in autoimmune arthritides such as rheumatoid arthritis (RA). This evidence concerns the gene TNF and rheumatoid arthritis.