While the study was underpowered to detect any single nucleotide polymorphisms (SNPs) significant at the whole-genome level, two SNPs within CAPN14 and MIATNB were identified with P < 10−5 for association with development of symptoms or bacteremia following oral S. Typhi or S. Paratyphi A challenge. This evidence concerns the gene CAPN14 and bacterial infectious disease with sepsis.