In prostate cancer cells and pancreatic ductal cancer cells, high expression of YAP upregulates the secretion of the CXCL5 chemokine, promotes the recruitment of MDSCs, and protects tumor cells from immune clearance63,64, whereas phosphorylation and inactivation of YAP lead to a decrease in Treg number and activity, thereby promoting anti-tumor effects65. This evidence concerns the gene CXCL5 and neoplasm.