Similarly, a recent study has revealed a non-cell-intrinsic, tumor-suppressing function of METTL3: ablation of METTL3 in macrophages has been found to contribute to the formation of an immunosuppressive microenvironment, including increased regulatory T cell (Treg) infiltration, and fewer Th1 cells and IFN-γ+CD8+ cells, thus facilitating tumor growth and metastasis. Here, METTL3 is linked to neoplasm.