Subsequently, through developing the five m6A regulators as a prognostic risk signature in lung adenocarcinoma, another study has similarly shown that patients with high-risk, rather than low-risk, lung adenocarcinoma have significantly higher PD-L1 levels, a lower proportion of CD8+ T cells, and better response to checkpoint blockade therapy, thus indicating that these five m6A regulators are highly correlated with immune infiltration levels and the immune checkpoint blockade response88. The gene discussed is CD274; the disease is lung adenocarcinoma.