However, whether AKAP4 induced the development of NSCLC by regulating the cAMP-PKA pathway, EMT progression, or both needs to be further verified in our future work, such as the co-treatment of the inhibitor of the cAMP-PKA pathway or the activator of EMT progression in siRNA-AKAP4 transfected H460 cells. The gene discussed is AKAP4; the disease is non-small cell lung carcinoma.