In addition, the biomarker of angiogenesis, VEGF (Figure 5d-e), was dramatically downregulated in the siRNA #1 and siRNA #2 groups (**p < 0.01, vs. siNC), indicating that the in vivo angiogenesis in H460 tumor tissues was suppressed by the knockdown of AKAP4. The gene discussed is VEGFA; the disease is neoplasm.