In addition, compared to siNC, E-cadherin expression was greatly upregulated, and N-cadherin, EphA2, and MMP-2 (Figure 7) were significantly downregulated in the siRNA #1 and siRNA #2 groups, respectively (**p < 0.01, vs. siNC), revealing that the EMT progression in H460 xenograft tumor tissues was suppressed by the knockdown of AKAP4. The gene discussed is EPHA2; the disease is neoplasm.