Type II is estrogen-independent and has a worse prognosis than type I.6 Among them, type I EC encodes genetic changes that are mostly associated with PI3K and Wnt pathway signaling abnormalities, KRAS mutations, and PTEN inactivation.4 In addition, PI3K/AKT/mTOR, the most important signal pathway, plays a pivotal role in tumor activities.7 This evidence concerns the gene PIK3CD and neoplasm.