Studies have shown that the IGF-1 mediates many biological processes, and it is closely associated with the occurrence and development of EC in cells.31–33 Besides, IGF-1 enhances the proliferation and metastasis of various cancers.34–38 In addition, IGF-1 has been shown to exert its biological effects through activation of the PI3K/AKT signaling pathway.39–41 This study evaluated the role of IGF-1, an agonist of the PI3K/AKT/mTOR signaling pathway, and showed that IGF-1 could effectively promote the phosphorylation of molecules in the PI3K/AKT/mTOR pathway. Here, PIK3CD is linked to cancer.