ADGRG1 and polymicrogyria: Finally, we introduced several missense mutations in the intracellular loops of GPR56 causing amino acid changes in potential phosphorylation sites and included also one mutation in the 7th transmembrane (TM) domain (L640R), which was reported to cause bilateral frontoparietal polymicrogyria (Piao et al, 2004) (Appendix Fig S3A).