Choose A549 for further verification because: 1) our previous study demonstrated that glucose transporter 1 (GLUT1) expression was significantly higher in A549 cells which is suitable for assessing the potential impact of Cor‐sugars by leveraging the tumor Warburg effect[20, 21, 22] and 2) A549 cells and its xenograft have been well characterized as a valuable model in rodent and zebrafish as well for evaluation not only of the tumor regression but also angiogenesis and metastases which allow us to survey in more details the mechanistic behavior of Cor‐sugars.[23, 24, 25]. This evidence concerns the gene SLC2A1 and neoplasm.