CDKN2A/BHDIFN‐IHD had shorter survival times than CDKN2A/BWT and downregulated immune response pathways, suggesting that poor prognosis in CDKN2A/BHD LUAD could potentially be attributed to an immunosuppressive tumor microenvironment owing to IFN‐I depletion. Here, CDKN2A is linked to neoplasm.