Conversely, expression of XCL1, which when produced by tumor cells may induce PD1/PD‐L1 interaction and dysfunction of CD8+ T cells in the tumor microenvironment [38], was higher in CDKN2A/BHDIFN‐IHD tumors than in CDKN2A/BHDIFN‐IWT tumors (Fig. 7G). This evidence concerns the gene CDKN2A and neoplasm.