Tissue PACAP has also been suggested as a marker for tumor progression, like cervical cancer (Jung et al. 2011), tumors of kidney, testis, prostate and thyroid gland, pancreas, and large intestine (Bardosi et al. 2016; Ferencz et al. 2019; Godlewski and Łakomy 2010; Lindner et al. 2021; Nakamura et al. 2014; Szanto et al. 2012; Tamas et al. 2016). This evidence concerns the gene ADCYAP1 and neoplasm.