Co-culture with adipocytes has been shown to increase FABP4 expression and FFA content in CRC cells, resulting in enhanced ATP production, EMT, cell migration, and invasiveness via a mechanism that was reversed by pharmacologic FABP4 inhibition, while increased FABP4 expression promoted metastasis formation in CRC xenograft models in mice.11,12 This FABP4/5-dependent mechanism of FFA uptake has also been described in ovarian, breast, and prostate carcinoma.4,6,8. The gene discussed is FABP4; the disease is colorectal carcinoma.