INS and cancer: While systemic alterations affecting hormone levels, insulin resistance, and gut microbiota may contribute to drive oncogenesis in obese patients, a prominent feature of CRC and other cancers in these patients is the preferential homing of tumors to the fat-rich visceral omentum or peri-glandular regions.3,4 Here, adipocytes and cancer cells establish a dynamic symbiotic relationship that profoundly influences tumor biology and clinical behavior.