SETD2 and neoplasm: Although inactivation of Rbm10, Rb1, or Apc did have similar effects on EGFR and KRAS mutant tumor growth, Serine/threonine kinase 11 (Stk11, also known as Lkb1) and SET domain containing 2, histone lysine methyltransferase (Setd2) inactivation had opposite effects in the two oncogenic settings.