Second, we hypothesized whether activation of CLEC5A (known to function as a PAMP receptor during infection) could in consequence provide a potent maturation signal to antigen-presenting cells (APC), in analogy to other PAMP, e.g., TLR (Toll-like receptors), or to activating myeloid receptors like CD40 or CD80. The gene discussed is CD80; the disease is infection.