As graphed in Figure 1(c), HHLA2 mRNA levels also increased significantly in breast invasive carcinoma (BRCA), CHOL, COAD, esophageal carcinoma (ESCA), glioblastoma multiforme (GBM), HNSC, KICH, KIRC, KIRP, acute myeloid leukemia (LAML), brain lower-grade glioma (LGG), lung adenocarcinoma (LUAD), LUSC, pancreatic adenocarcinoma (PAAD), pheochromocytoma and paraganglioma (PCPG), READ, stomach adenocarcinoma (STAD), thyroid carcinoma (THCA), uterine corpus endometrial carcinoma (UCEC), and uterine carcinosarcoma (UCS). The gene discussed is HHLA2; the disease is colon adenocarcinoma.