PIEZO1 and Hypertension: In the cardiovascular system, Piezo1 is required for angiogenesis, vascular maturation, and the baroreceptor reflex (14–18), Piezo1 required for the release of nitric oxide for blood pressure control mediates fluid shear stress sensing in endothelial cells (19), and is activated by stretch, involved in hypertension-dependent arterial remodeling in smooth muscle cells (20).