CASP1 and heart failure: The main pathological pathway discussed in relation to DCM involved regulating caspase-1, the hypothesis being that downregulating Kcnq1ot1 repressed activation of miR-214-3p which reduced expression of caspase-1 and its downstream inflammatory cytokines such as interleukin 6, interleukin 10, and the IL-1 family, all of which are involved in DCM induced heart failure (202).