While it has been proposed that TRAF5 can be partially compensated by TRAF2 (158), a deficiency of TRAF5 in bone-marrow derived cells did not affect atherosclerosis in LDLR−/− mice (103), rendering effects on lipid deposition and lower numbers of Treg cells in plaques as indirect effects. The gene discussed is TRAF2; the disease is atherosclerosis.