ACE and Stroke: The benefits of beta blockers were not apparent in the prevention of new-onset stroke for both the high-burden and low-burden sub-cohorts, and the existing data regarding this is somewhat mixed; Ziff et al. previously reported that compared with a placebo group, the risk of stroke decreased in hypertensive patients treated with beta blockers, but beta blockers were less effective than angiotensin converting enzyme inhibitors/angiotensin receptor blockers and calcium channel blockers (16).