However, how PSRC1 interacts with GRN is unclear but we found that these genes were connected via other genes that were related to cardiovascular diseases or lipid metabolism (e.g., APP, APOA1, ARFGAP1, CALR, SAMD3, LRP2, AKT2, BGN, PIK3R2, HSPG2, YY1, TGM2) (Supplementary Figure S3). Here, APP is linked to cardiovascular disorder.