The findings suggested that regulatory genetic variants in PSRC1 may affect CAD risk through altering CELSR2, PSRC1, and SORT1 gene expression in liver cells and circulating granulins and apolipoprotein B proteins, and moreover, the gene expression and circulating protein levels were genetically associated with LDL-C and CAD and may be novel risk factors for CAD. This evidence concerns the gene GRN and coronary artery disorder.