For EC injury induced by an inflammatory state see Figure 8 pathways: ↑oxLDL-(pw51)-Hypercholesterolemia-(pw51)-↑foam cell-(pw81)-↑NFkβ-(pw82)-↑IL-6, IL-8-(pw76)-↑platelet factors-(pw74)-↑inflammatory state-(pw110)-↑EC injury. The gene discussed is CXCL8; the disease is familial hypercholesterolemia.