Inflammatory state:Depression-(pw7b)-central nervous system-(pw27)-↑cortisol-(pw48)-liver-(pw14)-↑blood glucose-(pw54)-PI3K:MAPK-(pw69)-↑insulin resistance-(pw70)-↑angiotensin II-(pw88)-renin-(pw50)-↑TNFα-(pw41)-↑Inflammatory state. This evidence concerns the gene REN and major depressive disorder.