CCL21 and cystic kidney disease: For example, downregulation of SLC family members has also been observed in two further animal models that develop renal cysts: a murine model for the renal cysts and diabetes (RCAD) syndrome (Niborski et al., 2021) and a mouse model linked to Birt–Hogg–Dubé (BHD) syndrome (Centini et al., 2018).