AKT1 and neoplasm: To further determine whether inhibiting Akt/ERK signaling is essential for 4MOD to exert its anti-tumor effect on BC cells, we added Akt specific agonist SC79 in combination with 4MOD in J82 and UMUC3 cells, As shown in Figures 7A,B, 4MOD and SC79 have shown varying degrees of antagonistic effect, the ability of 4MOD to inhibit cancer cell proliferation was reduced after adding SC79.