SPINK1 and posterior cortical atrophy: Using a comprehensive quantitative proteomic analysis, we previously identified and demonstrated that levels of cysteine rich secretory protein 3 (CRISP3) and serine peptidase inhibitor Kazal type 1 (SPINK1) were upregulated in expressed prostatic secretion (EPS)-urine of patients with PCa, compared to those of patients with benign prostatic diseases (6).