It was reported that the m5C regulator YBX1 maintained the mRNA stability of the oncogenic gene heparin binding growth factor (HDGF) by binding to m5C methylated sites and recruiting ELAVL1, thus exerting an oncogenic role in bladder cancer development through the activation of HDGF (Chen et al., 2019). This evidence concerns the gene HDGF and urinary bladder carcinoma.