FOXO3 and malignant colon neoplasm: Moreover, relatively high co-expression scores were also observed for RUNX2/ETS1, RUNX2/FOXO3, HNF1B/HNF4A, and HNF1B/FOXA3 (Figure 8B), suggesting that the DETFs associated with DARs might work together and be responsible for 5-FU resistance in colon cancer cells.