The genetic loss of Atg5 and Atg7 increased the levels of SQSTM1/p62, oxidative stress, mitochondrial swelling, and genomic damage observed in the primary hepatocytes, and the deletion of the p62 gene reduced the tumor size in Atg7 deficient hepatic tumors (Umemura et al., 2016). The gene discussed is SQSTM1; the disease is neoplasm.