MAPT and Alzheimer disease: Recently, it has been proposed that Tau phosphorylation at microtubule domain region at early stages could protect the hippocampal circuit from overexcitation in 1-month-old 3xTg mice (a model of AD) by directly interacting with the pyramidal circuitry that spontaneously generates theta oscillations (Mondragón-Rodríguez et al., 2018).