A first team reported that the application of mHFD (60% fat) during gestation and lactation impaired short- and long-term spatial memory and increased the number of Tau-positive neurons in the hippocampus without altering Aβ peptides level, suggesting that mHFD exacerbated Tau pathology and may sensitize to the development of AD (Martin et al., 2014). The gene discussed is MAPT; the disease is Alzheimer disease.