Although ABT263 is one of the most potent and broad-spectrum senolytics identified to date (Zhu et al., 2015, 2017; Chang et al., 2016), Bcl-xL inhibition with ABT263 or other small molecular inhibitors induces platelet apoptosis and results in severe thrombocytopenia, which prevents their use in the clinic—even for tumor patients (Gandhi et al., 2011; Souers et al., 2013; Leverson et al., 2015; Ashkenazi et al., 2017). This evidence concerns the gene BCL2L1 and Thrombocytopenia.