As one of the most important Bcl-2 family members, Mcl-1 plays critical roles in suppressing apoptosis in tumor cells (Ramsey et al., 2018; Mukherjee et al., 2020; Seiller et al., 2020), which however may not affect the survival of SnCs, as inhibition of Mcl-1 with its specific inhibitor did not cause cell death in SnCs (Chang et al., 2016; He et al., 2020b). This evidence concerns the gene BCL2 and neoplasm.