As shown in Figure 5A, to further verify the effect of M-MDSC supernatant treatment on myofibroblast differentiation in tissue resident MSCs in the context of renal fibrosis, mice were administered M-MDSC supernatant following renal unilateral ischemia-reperfusion injury (IRI), with or without IL-15 blockade by IL-15 mAbs (10 μg/mL). The gene discussed is IL15; the disease is renal fibrosis.