Previous research showed that IL-15 expression was decreased in transplants with renal dysfunction and human inflammatory nephropathies, including focal segmental glomerulosclerosis, diabetic nephropathy, IgA nephropathy, hypertensive nephropathy, minimal change disease, membranous glomerulonephritis and thin basement membrane disease (Devocelle et al., 2019). Here, IL15 is linked to diabetic kidney disease.