Guo et al. (2020) found that IL-15/IL-15Ra complex treatment diminished MDSCs in murine breast tumors. We next investigated whether IL-15 participated in regulating MDSCs during renal fibrosis. Interestingly, our data demonstrated that M-MDSC supernatant treatment increased bone marrow, spleen and renal infiltration of M-MDSCs at 24 h after IRI, and this effect could be reversed by IL-15 mAbs. In addition, IL-15 treatment upregulated M-MDSCs in vitro. Here, IL15 is linked to renal fibrosis.