Loss of catp-6 in C. elegans and loss of ATP13A2 in cells derived from patients with Parkinson’s disease, impact lysosomal function by preventing lysosomal acidification and lysosomal enzyme maturation, which ultimately affects the degradative capacity of lysosomes (Dehay et al., 2012b; Anand et al., 2020). The gene discussed is ATP13A2; the disease is Parkinson disease.