VPS34 is part of a tetramer complex composed of serine/threonine-protein kinase VPS15, beclin-1 (BECN1), and either BECN1-associated autophagy-related key regulator (ATG14) or UV radiation resistance-associated gene (UVRAG) (denoted as Class III PI3K complex I or Class III PI3K complex II, respectively) (Kang et al., 2011; Quan and Lee, 2013; Bento CF. The gene discussed is UVRAG; the disease is cystic fibrosis.