Loss of Ppt1 in mice, as well as PPT1 in various human models (melanoma cells, patient-derived fibroblasts, patient brain tissues), elevates both p62-positive aggregates and Ub-positive proteins (Figure 3) (Atiskova et al., 2019; Rebecca et al., 2019; Sarkar et al., 2020; Yun et al., 2020). The gene discussed is PPT1; the disease is melanoma.