In melanoma and neuroblastoma cell lines subjected to proteotoxic stress, overexpression of full-length ATP13A2, catalytically-inactive ATP13A2, or the N-terminal domain of ATP13A2 reduces the accumulation of Ub-conjugated proteins by serving as a scaffold for trafficking intracellular cargo (Figure 3) (Demirsoy et al., 2017). This evidence concerns the gene ATP13A2 and melanoma.