miR-1269a can down-regulate the expression of SPATS2L and LRP6, thereby inhibiting the proliferation of liver cancer cells; while miR-1269a rs73239138 can inhibit the down-regulation of SPATS2L and LRP6 by miR-1269a to promote the occurrence and development of cancer (Min et al., 2017). The gene discussed is SPATS2L; the disease is cancer.