AKT1 and osteosarcoma: In addition, inhibition of lncRNA UCA1 reduced tumorigenesis and metastasis via targeting miR-513b-5p/E2F5 axis and CREB1-mediated EMT and PI3K/AKT/mTOR axis in osteosarcoma (Ma H. et al., 2019; Zhang et al., 2021).