LGALS9 and serum lipopolysaccharide activity: Taken together, this experiment has verified the significance of Gal-9-mediated MSC therapy in relief of endotoxemia, which mainly manifested as attenuating circulating pro-inflammatory mediator secretion, promoting macrophage polarization to M2-subtype, inducing the increase of Treg population, and facilitating the alleviation of multiple organ injury.