A combination of CFTR modulators that include a corrector, tezacaftor/VX-661 (Teza), which repairs misfolded CFTR protein, plus a potentiator, ivacaftor/VX-770 (Iva), which improves CFTR opening and increases chloride transport, is recently used in CF clinics (Clancy et al., 2019). Here, CFTR is linked to cystic fibrosis.