Given that autophagy is defective in CF macrophages (Abdulrahman et al., 2011; Abdulrahman et al., 2013; Tazi et al., 2016) and epithelial cells (Luciani et al., 2010), we then determined if CFTR modulators would improve autophagy activity in F508del macrophages. The gene discussed is CFTR; the disease is cystic fibrosis.