Moreover, exposure to A. muciniphila is correlated with enhanced trafficking of CC-chemokine receptor 9 (CCR9)-expressing T helper cells into mesenteric lymph nodes, following the accumulation of CD4+ CXCR3+ T cells into tumor-draining lymph nodes, finally leading to enhanced cytotoxic T cell response as well as reduced regulatory T cell ratio in the TME (Figure 1B) (20, 60). The gene discussed is CD4; the disease is neoplasm.