The other category comprises anti-EGFR monoclonal antibodies, which mainly act on the extracellular domain of EGFR, competitively inhibiting the binding of various ligands (such as EGF and TGF-α) to the receptor and blocking its phosphorylation, which finally leads to the loss of EGFR activity, inhibition of tumor growth, and induction of apoptosis. This evidence concerns the gene EGFR and neoplasm.