(8) found that liver cancer cells under oxidative stress activate their own P62-Keap1-NRF2 signaling pathway to up-regulate target genes involved in iron and ROS metabolism downstream of NRF2, such as quinone oxido-reductase 1 (NQO1), heme oxygenase 1 (HO-1) and ferritin heavy chain-1 (FTH1), thereby enhancing Sorafenib’s ferroptosis resistance (59). Here, HMOX1 is linked to liver cancer.