Serine threonine tyrosine kinase 1 (STYK1) is highly expressed in NSCLC cells, which in turn promotes the expression of GPX4 and promotes the Proliferation of lung cancer cells, which attenuates a variety of mitochondrial abnormalities caused by ferroptosis, leading to suppression of ferroptosis in NSCLC. The gene discussed is STYK1; the disease is non-small cell lung carcinoma.