Wee1 inhibition by AZD1775 has been shown to induce in vitro and in vivo synergistic tumor cell killing with several DNA damaging therapies including IR (55) and chemotherapeutics like cisplatin, paclitaxel doxorubicin, 5-fluorouracil, and gemcitabine (53, 72–74). The gene discussed is WEE1; the disease is neoplasm.