RPA1 and cancer: As high replication stress in cancer cells - due to the high level of baseline DNA damage per se, but also to the resulting exhaustion of factors needed for both repair and replication, such as RPA (120) – contrasts from the stress in normal cells, even in highly proliferative tissues, and cancer cells often have an increased reliance on the G2/M checkpoint, a therapeutic window is achieved in an example of a conditional synthetic lethality.