HDACs can also enhance genes related to angiogenesis, cell invasion, and migration and immune regulation to promote cancer development, such as vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), HIF-1α, major histocompatibility complex (MHC), and human leukocyte antigens (HLA) (24–29). This evidence concerns the gene NOS3 and cancer.