It has been shown that both TGF-β and WNT5A play a crucial role in the stimulation of EMT in tumor cells: WNT5A stable melanoma cells transfectants indicate a spindle shape accompanied by increased vimentin expression and decreased E-cadherin expression (16), and TGF-beta mediated EMT is regulated by the SNAIL1-SMAD3/4 transcriptional complex, which acts as a suppressor of E-cadherin expression (17). Here, CDH1 is linked to melanoma.